1. striving
2. nisus, strain, attempt, effort, endeavor, endeavour, try, pain
3. hurting, symptom, pain
4. painfulness, feeling, pain
5. painful sensation, somesthesia, somaesthesia, somatesthesia, somatic sensation, pain
6. pain in the neck, nuisance, unpleasant person, disagreeable person, annoyance
6. bother, botheration, pain, infliction, pain in the neck, pain in the ass, negative stimulus