GeneralConnection.com ➔ Dictionary
Dictionary Search

secretase

Synonyms

Noun

1. enzyme

Usage
Charting γ-secretase substrates by explainable AI - Nature
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Phase 2 GABriella Study Represents First Step in Testing Selective Novel Y-Secretase Modulators for Prodromal Alzheimer Disease - Neurology Live
Explainable AI helps decode the substrate specificity of γ-secretase enzyme - News-Medical
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature
Zolucatetide Receives Orphan Drug Designation for Desmoid Tumors - CancerNetwork
Molecular mechanism of substrate recognition and cleavage by human γ-secretase - Science | AAAS
Therapeutic effects of a novel synthetic α-secretase - Frontiers
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 - PNAS
Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease - Frontiers
Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate - PNAS
Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform - Nature
Defining the minimum substrate and charge recognition model of gamma-secretase - Nature
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature
Structural basis of Notch recognition by human γ-secretase - Nature
Structural basis of human γ-secretase inhibition by anticancer clinical compounds - Nature
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease - Nature
Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits - Frontiers
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature
EBP1 potentiates amyloid β pathology by regulating γ-secretase - Nature
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy - Nature
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state - PNAS
An atomic structure of human γ-secretase - Nature
Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation - PNAS
γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation - Nature
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition - Nature
Gamma-secretase-dependent signaling of receptor tyrosine kinases - Oncogene - Nature
Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex - Nature
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding - Nature
Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease - Science Partner Journals
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors - The New England Journal of Medicine
γ-secretase directly sheds the survival receptor BCMA from plasma cells - Nature
A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss - Nature
Role of cholesterol in substrate recognition by $$\gamma$$ γ -secretase - Scientific Reports - Nature
Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis - Nature
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) - The Lancet
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator - PNAS
SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions - Science | AAAS
Three-dimensional structure of human γ-secretase - Nature
Efficient production of a mature and functional gamma secretase protease - Nature
η-Secretase processing of APP inhibits neuronal activity in the hippocampus - Nature
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio - Nature
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease - Nature
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum - Rockefeller University Press
Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates - Rockefeller University Press
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS
Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature
Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease - Wiley
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production - Nature
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms - Frontiers
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention - Rockefeller University Press
Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice - Journal of Neuroscience
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase - Nature
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities - Science | AAAS
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks | Scientific Reports - Nature
GSAP modulates γ-secretase specificity by inducing conformational change in PS1 - PNAS
Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor - Science | AAAS
Aβ-Generating Enzymes : Recent Advances in β- and γ-Secretase Research - ScienceDirect.com
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease - The New England Journal of Medicine
BACE1 is the major β-secretase for generation of Aβ peptides by neurons - Nature
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling - Nature
1999: Identifying the key enzyme β-secretase - Nature
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors - Frontiers
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease - Nature
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis - Nature
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein - PNAS
Is a Cellular ‘Stalled Engine’ Causing Alzheimer’s? - Being Patient
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion | Molecular Psychiatry - Nature
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence - Nature
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease - Nature
Modulation of γ-secretase specificity using small molecule allosteric inhibitors - PNAS
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 - PNAS
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus - PNAS
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase - Frontiers
Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease - Journal of Neuroscience
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma - Nature
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment - Journal of Neuroscience
Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures - The New England Journal of Medicine
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase - Nature
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies - Nature
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase - Nature
An Accomplice for γ-Secretase Brought into Focus - Science | AAAS
Targeting the β secretase BACE1 for Alzheimer's disease therapy - The Lancet
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors - Nature
Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer’s disease - Nature
Influence of apolipoprotein E (apoE) on ADAM10 secretase in cerebrospinal fluid of older adults with Alzheimer’s disease - Wiley
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation - Nature
γ-Secretase: proteasome of the membrane? - Nature
AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling - American Heart Association Journals
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease - Frontiers
γ-Secretase inhibitors plus anti-BCMA chimeric antigen receptor T cells - The Lancet
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients - PNAS
Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid - Journal of Neuroscience
The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus - Journal of Neuroscience
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 - Nature
Foreign Language Equivalents
Foreign Language Equivalents of 'secretase'
Language Equivalent   Language Equivalent
French    Spanish
Misspellings - Typos
secretsse,   secretade,   secrettase,   secretasee,   sercetase,   secretasr,   seccretase,   secretae,   secretse,   secreatse,   secretasse,   secreetase,   secrwtase,   secreyase,   secertase,   secrerase,   secrretase,   sexretase,   secrease,   secretas,   ecretase,   ssecretase,   aecretase,   seceetase,   escretase,   srcretase,   secretasw,   secrtease,   secretaase,   sectetase,   seretase,   scretase,   sceretase,   secrrtase,   secretsae,   secretaae,   swcretase,   seecretase,   decretase,   secetase,   secretaes,   sevretase,   secrtase
Words Starting with Letter - 'A'
a a battery a billion
a bit a bit much a capella singing
a cappella singing a couple of a few
a fortiori a good deal a great deal
a horizon a hundred a hundred and one
a hundred thousand a hundred times a kempis
a la carte a la mode a level
a little a lot a million
Go to Page 1              Go to Page 2 »   
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z