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secretase

Synonyms

Noun

1. enzyme

Usage
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature
Glycemic variability associated with gamma secretase inhibitor therapy in a type 1 diabetic patient undergoing treatment for desmoid tumor: a case report - Frontiers
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Lilly bets up to $1B+ with AlzeCure in search for next Alzheimer’s act - BioSpace
Alzheimer’s-in-a-Dish™: Developing Drugs for Disease Prevention and Treatment - Technology Networks
Phase 2 GABriella Study Represents First Step in Testing Selective Novel Y-Secretase Modulators for Prodromal Alzheimer Disease - NeurologyLive
Molecular mechanism of substrate recognition and cleavage by human γ-secretase - Science | AAAS
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform - Nature
Therapeutic effects of a novel synthetic α-secretase - Frontiers
Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS
Charting γ-secretase substrates by explainable AI - Nature
Secretase promotes AD progression: simultaneously cleave Notch and APP - Frontiers
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons - Journal of Neuroscience
Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease - Science Partner Journals
Defining the minimum substrate and charge recognition model of gamma-secretase - Nature
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease - Frontiers
Structural basis of human γ-secretase inhibition by anticancer clinical compounds - Nature
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease - Nature
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease - Nature
Structural basis of Notch recognition by human γ-secretase - Nature
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy - Nature
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature
EBP1 potentiates amyloid β pathology by regulating γ-secretase - Nature
An atomic structure of human γ-secretase - Nature
γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation - Nature
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding - Nature
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition - Nature
γ-secretase directly sheds the survival receptor BCMA from plasma cells - Nature
Gamma-secretase-dependent signaling of receptor tyrosine kinases - Oncogene - Nature
Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex - Nature
Role of cholesterol in substrate recognition by $$\gamma$$ -secretase | Scientific Reports - Nature
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio - Nature
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors - The New England Journal of Medicine
A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss - Nature
Three-dimensional structure of human γ-secretase - Nature
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state - PNAS
Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate - PNAS
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors - Frontiers
A promising new γ-secretase modulator for Alzheimer’s disease - Rockefeller University Press
Efficient production of a mature and functional gamma secretase protease - Nature
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production - Nature
Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis - Nature
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator - PNAS
1999: Identifying the key enzyme β-secretase - Nature
SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions - Science | AAAS
BACE1 is the major β-secretase for generation of Aβ peptides by neurons - Nature
η-Secretase processing of APP inhibits neuronal activity in the hippocampus - Nature
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention - Rockefeller University Press
Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS
Substrate-targeting γ-secretase modulators - Nature
The beta secretase BACE1 regulates the expression of insulin receptor in the liver - Nature
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms - Frontiers
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease - The New England Journal of Medicine
GSAP modulates γ-secretase specificity by inducing conformational change in PS1 - PNAS
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) - The Lancet
Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein - PNAS
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase - Nature
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner - Nature
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks - Nature
Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells - Nature
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling - Nature
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease - Nature
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma - Nature
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence - Nature
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion | Molecular Psychiatry - Nature
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS
The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential - Journal of Neuroscience
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes - Nature
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment - Journal of Neuroscience
γ-Secretase and Human Disease - Science | AAAS
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease - Nature
DNA damage-inducing agents elicit γ -secretase activation mediated by oxidative stress - Nature
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase - Nature
Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid - Journal of Neuroscience
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis - Nature
β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology - Nature
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients - PNAS
γ-Secretase: proteasome of the membrane? - Nature
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production - Nature
γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin - Journal of Neuroscience
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 - PNAS
Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures - The New England Journal of Medicine
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 - Nature
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells - Nature
Structural basis of human γ-secretase assembly - PNAS
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease - Neurology® Journals
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies - Nature
Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease - Journal of Neuroscience
The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus - Journal of Neuroscience
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease - Nature
Targeting the β secretase BACE1 for Alzheimer's disease therapy - The Lancet
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1 | Scientific Reports - Nature
Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase - Journal of Neuroscience
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation - Nature
Foreign Language Equivalents
Foreign Language Equivalents of 'secretase'
Language Equivalent   Language Equivalent
French    Spanish
Misspellings - Typos
secretse,   secretsae,   swcretase,   secetase,   seceetase,   secreatse,   secrease,   secretasr,   decretase,   secrettase,   secretaase,   secreetase,   seretase,   secretasw,   secretade,   secretaes,   sevretase,   secrtease,   secretas,   secretae,   secrretase,   ecretase,   seccretase,   secrrtase,   secretsse,   sceretase,   secretasse,   scretase,   srcretase,   sexretase,   secreyase,   aecretase,   secretaae,   secertase,   secrtase,   secretasee,   seecretase,   sercetase,   ssecretase,   secrwtase,   sectetase,   secrerase,   escretase
Words Starting with Letter - 'A'
a a battery a billion
a bit a bit much a capella singing
a cappella singing a couple of a few
a fortiori a good deal a great deal
a horizon a hundred a hundred and one
a hundred thousand a hundred times a kempis
a la carte a la mode a level
a little a lot a million
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